In-Vitro Efficacy Investigation and an Open-Label, Single-Arm Clinical Study of a Gentle Micropeeling Cream for Sensitive and Non-Sensitive Skin

Skin exfoliators, specifically alpha and beta hydroxy acids, have been shown to improve overall skin health the clinical signs of aging. A micropeeling cream was developed with acids a brown algae extract efficacy tolerability were evaluated in two parts. In first part pre-clinical investigation, placebo control by ELISA, immunostaining, qPCR an activity assay using ex vivo vitro models. second study, 36 female subjects enrolled for bioinstrumental measurements, visual imaging evaluation 28 days. Fifty percent had sensitive skin. The ex-vivo study showed increase loricrin, superoxide dismutase 2, extracellular matrix expression, without stimulating inflammatory biomarkers. dermatologist observed significant enhancement all parameters at day 28, radiance, homogeneity, roughness significantly better after application. desquamation pore diameter improvement 7. improved markers associated aging protection vivo. It well tolerated, even on skin, provided fine lines, texture, characteristics.